Streamlining Small Molecule R&D with BIOVIA Pipeline Pilot

Strategies to Modernize Combinatotial Chemistry

Identifying what molecules to test when designing a therapeutic is a fundamental challenge to medicinal chemists. Candidates need to satisfy a variety of parameters, and building combinatorial libraries has proven to be a massive help for researchers to narrow the scope of their searches. However, managing the catalogs of molecules that form the basis of these libraries has proven time and again to be costly and time consuming. This case study explores how a leading pharmaceutical company used BIOVIA Pipeline Pilot to automate their compound selection process when building combinatorial libraries, removing significant bottlenecks in high-throughput screening and lowering the cost to manage their combinatorial chemistry catalog by 50%.