Drug repurposing is a discovery strategy that identifies drugs known to be safe for humans as potential treatments in new therapeutic indications. Systems biology can help to predict the best way to reduce the pathogenicity of a virus in the body.
BIOVIA Living Map is a service on the Dassault Systèmes 3DEXPERIENCE® platform that provides automated knowledge access along with modelling and simulation capabilities supporting systems biology.
In this application brief, we describe an attempt to reposition an approved drug to reverse virus-induced disease phenotypes and our discovery of a virus-host protein interaction with the potential to be effective. Our Living Map model suggests that inhibition of the PLP-ISG15 interaction would restore innate immunity, likely leading to a reduction of virus replication at an early stage of virus infection.